top of page

TransHeps

Serving global Pharma Drug Developer and Regulators by providing the MetaHeps assay as a decision-enabling drug development tool for DILI causality assessment in clinical studies.

Using the power of the MetaHeps assay.

AdobeStock_718024539.jpeg
Element-orange_0,5x.png

MetaHeps Technology

MetaHeps cells are derived from monocytes taken from individual patients with suspected DILI, carrying the genetic makeup and immunogenicity of the donor (e.g., HLA haplotype).

Blood
 sample

30-50mL of fresh blood sample or frozen PBMCs from patients

MetaHeps  differentiation

Cells with donor specific characteristics

12-14 days

Re-challenge

Culture is exposed
to all potential
perpetrator drugs and combinations thereof

2 days

Toxicity assessment

Study termination and  LDH analysis

1 day

Data

Analysis

Database of values across DILI, non-DILI controls, and normal healthy volunteer samples

1 day

Drug-Induced Liver Injury (DILI)

DILI is an acute from of liver injury caused by drug intake. Most DILI cases are unpredictable and idiosyncratic (iDILI).

AdobeStock_729890269.jpeg

Products & Services

We are the DILI company offering cutting edge laboratory services and advisory expertise for Drug-Induced Liver Injury (DILI) in clinical trials.

What we can do for you

Element-blue-2_0,5x.png
Expert Advisory Services/Consulting

Our DILI team of experienced scientists with proven expertise in clinical and experimental hepatology ensures the highest quality standards. Analysis of clinical DILI signals, hypothesis generation, experimental design of new study proposals, data analyses, reporting.

MetaHeps® ASSAY

Experimental DILI causality assessment. Application and logistics to bring the MetaHeps assay in clinical studies – trial design, advice on sample preparation, shipment, data analyses, data interpretation and reporting.

Mechanistic Investigations

Drug-induced hepatocellular transporter inhibition:  monolayer, vesicular and transwell transport assays: OATP1B1, OATP1B3, OATP2B1, NTCP, BSEP, MRP2, and MDR3.​

Mitochondrial Dysfunction: Glucose/Galactose ATP assay in HuH7, HepG2 and cell lines upon request. ​

bottom of page